Vti Proteins: Beyond Endolysosomal Trafficking
نویسندگان
چکیده
منابع مشابه
Hyperactivated endolysosomal trafficking in melanoma
Cutaneous melanoma is an increasingly frequent solid tumor that accounts for 80% of skin cancer-related deaths. Characterized by a complex and heterogeneous genetic background and a notorious functional plasticity, melanoma has shifted from a “black box” to a paradigm of how basic research can be successfully translated into significant improvements of patient prognosis [1]. Indeed, the identif...
متن کاملCHAPTER 5 Vti 1 A and Neurobeachin : two trafficking proteins with different fates ?
The trans-Golgi/early endosomal SNARE protein Vti1a (Vacuolar protein sorting ten p tail interacting 1a) and the brain-enriched scaffolding protein Neurobeachin (Nbea) have both been implicated in protein transport. We have shown in our earlier study that these two proteins reside in the same cellular compartment. In this study we set out to examine the impact of Nbea loss on the subcellular di...
متن کاملSynaptojanin 1 Is Required for Endolysosomal Trafficking of Synaptic Proteins in Cone Photoreceptor Inner Segments
Highly polarized cells such as photoreceptors require precise and efficient strategies for establishing and maintaining the proper subcellular distribution of proteins. The signals and molecular machinery that regulate trafficking and sorting of synaptic proteins within cone inner segments is mostly unknown. In this study, we show that the polyphosphoinositide phosphatase Synaptojanin 1 (SynJ1)...
متن کاملThe role of TRPMLs in endolysosomal trafficking and function.
Members of the Transient Receptor Potential-Mucolipin (TRPML) constitute a family of evolutionarily conserved cation channels that function predominantly in endolysosomal vesicles. Whereas loss-of-function mutations in human TRPML1 were first identified as being causative for the lysosomal storage disease, Mucolipidosis type IV, most mammals also express two other TRPML isoforms called TRPML2 a...
متن کاملSphingosine kinases and their metabolites modulate endolysosomal trafficking in photoreceptors
Internalized membrane proteins are either transported to late endosomes and lysosomes for degradation or recycled to the plasma membrane. Although proteins involved in trafficking and sorting have been well studied, far less is known about the lipid molecules that regulate the intracellular trafficking of membrane proteins. We studied the function of sphingosine kinases and their metabolites in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuroscience
سال: 2019
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2018.11.014